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650-575 | LCSAS Cisco Lifecycle Services Advanced Security

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650-575 - LCSAS Cisco Lifecycle Services Advanced Security - braindump

Vendor Cisco
Exam Number 650-575
Exam Name LCSAS Cisco Lifecycle Services Advanced Security
Questions 178 Q & A
Recent Update July 13, 2018
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650-575 exam Dumps Source : LCSAS Cisco Lifecycle Services Advanced Security

Test Code : 650-575
Test Name : LCSAS Cisco Lifecycle Services Advanced Security
Vendor Name : Cisco
Q&A : 178 Real Questions

LCSAS Cisco Lifecycle Services

How 3M and Cisco use "expertise systems" to inspire Innovation | killexams.com Real Questions and Pass4sure dumps

As an advisor and consultant to some of the world's biggest and most creative corporations, during the last few years I've seen a dramatic shift within the C-Suite.

today's executives recognize the urgency to discover and put money into disruptive technology. whether it's blockchain, self reliant cars or the web of things, the frenzy makes feel. Strategic innovators scan with expertise. Investing time and money in something unproven is price the chance. if you don't disrupt, they say, you'll finally be disrupted.

I've had the privilege to do a little work with two massive businesses universal for his or her long-term center of attention and investments in innovation - 3M and Cisco. Like many organizations, they follow disruptive applied sciences to construct their future products and functions.  however 3M and Cisco also use a similar approach to their know-how-inspired innovation to make it a sustainable and repeatable technique. here's how the they do it:

explore the Disrupters, however do not stop There

3M recently established an initiative on "linked Roads" to tap into the approaching disruption from self sufficient vehicles.  3M's scientists are developing new materials for street signals so sensors on automatic motors can music signals as they velocity by way of, practically enabling both people and machines to navigate roadways together in a authentic way by "studying" the same indications.

Cisco applied the vigor of the information superhighway of issues through the use of data from lots of related instruments to create what it calls "intent-based mostly networking" - aggregating large amounts of records promises to ultimately display a new level of synthetic intelligence.

no matter if these experiments develop into the subsequent big component for 3M and Cisco is any person's wager. that's because the biggest challenge with step forward innovation is that the market success of any given product or carrier according to new expertise is totally unpredictable.

for most businesses, the query is never even if to scan, but somewhat a way to continually create new profits streams over time. long-term innovators like 3M and Cisco appreciate that in today's world enamored by way of the allure of disruptive expertise, it be essential to investigate the expertise online game changers, whereas no longer become blinded by way of them. bound, a large innovation might also come from a new to the realm know-how, but leveraging existing technical capabilities is equally essential, if no longer a fair greater predictable driver of sustainable enterprise increase.

Use expertise systems to pressure lengthy-term boom

notwithstanding they're in fully different industries, 3M and Cisco both use "expertise platforms" to e-book their innovation efforts. These groups admire they want a method to encourage innovation that enormously improves upon state-of-the-art offerings or creates totally new market opportunities - although these innovations aren't always "disruptive" per se.

A "platform" is a technology that will also be used as the basis for growing various items or services.  one among 3M's most noted know-how systems is "adhesives," which has allowed the company to create products like submit-It Notes, super Sticky Easel Pads, Scotch tape, stretch free up Command strips, efficiency adhesives to exchange rivets on airplanes, scientific tape, and the listing goes on.

The issue in most groups is that leadership either only goes for the large bets or gets caught in a single-minded focal point on the small stuff. If we simplest swing for the fences, we'll omit the chance to rating on singles, doubles, or triples as smartly. technology platforms supply a means to ranking on quite a lot of forms of improvements that support win the lengthy online game.

outline Your structures

Most companies consider the theory of "core knowledge" - the combination of abilities, supplies, and strengths that aid differentiate an organization in the marketplace. while technology might contribute to a company's ordinary core advantage, expertise systems are a a lot more selected option to take into account and take knowledge of know-how to power innovation.

3M, as an instance, makes use of a "periodic table" structure to classify 46 technology platforms into four areas that focal point its innovation efforts: substances, tactics, capabilities, and purposes. in accordance with Gayle Schueller, 3M's vp of recent structures, "3M's expertise systems support guide efforts to keep world-category capabilities and differentiated capabilities that develop selected products, services, methods, and enterprise fashions."

Cisco applies a special strategy to defining its platforms, though the influence is similar. Cisco's features business structures some of its innovation platforms in keeping with what's necessary to carry services for open supply software. The idea is basic. based on Stan Baginskis, Cisco services Sr. Director of expertise strategy and boom, "Accelerated adoption of open supply utility creates a chance to supply functions to aid our consumers use the application to its full talents."

To the layperson, open source application may be almost unparalleled (like FD.io, OpenDaylight, and so forth.), however many of these equipment have turn into the technical backbones that help run the networks, safety, storage, and cloud capabilities of many large corporations. because the application is open supply, the software itself is free, however businesses are left to their own contraptions to enforce it.

Cisco makes use of a simple framework to describe its structures, each of which is a step in the life cycle of how agencies select, customize, enforce, and support their utility tools. as an instance, Cisco views its platforms as Advisory, Implementation, development, Technical aid, answer Validation, and Optimization. each and every of those structures comprise quite a lot of provider offerings that help clients benefit from their utility.

Make platforms Strategic

no longer every technology is a platform for every enterprise.  Some applied sciences can be valuable for constructing specific items, but they may also not be the groundwork for future aggressive expertise via innovation. 3M, as an example, makes use of paper in items like put up-It notes and easel pads. but 3M sources paper from many suppliers, so the company doesn't view it as a core expertise platform. Any business can purchase bulk paper to make use of in their products, which is why it be now not commonly seen as a differentiator when it involves innovation. due to this fact, 3M makes a speciality of platforms it could handle and follow to new products in methods that almost all rivals can not.

in a similar fashion, Cisco is rarely making an attempt to write down code to advance every open supply software device. quite, Cisco looks at the particular software where valued clientele have the greatest need and Cisco has the most expertise to offer. as an instance, of the dozens of open supply utility tools accessible, some are greater susceptible to security breaches than others. Cisco focuses on constructing out its safety consulting features specially geared to consumers the usage of the utility that may most benefit from extra protection aid, pretty much defining its platform (e.g., protection implementation) on the subject of a given open supply tool.

expertise systems serve as the groundwork for product and service innovation, and the best structures aid create market differentiation.

strengthen platforms with clients

know-how is barely technology except it solves a consumer issue. In trendy world focused on design pondering, the customer experience, and customer centricity, it may well think counter-intuitive to center of attention on know-how-driven innovation. but the foremost know-how systems naturally outline the consumer advantages or problems that they could support handle, so that they're related to what basically adds value to the market.

Cisco, as an example, started working with an enormous US wireless communications tremendous to help the business optimize an open source records analytics tool referred to as PNDA (pronounced "Panda"). a lot of records passes during the carrier issuer's community every day in the form of calls, texts, movies, augmented and digital fact games, and other cell web site visitors.  PNDA helps businesses collect, seize, and analyze this facts whereas growing visual stories for what's occurring across the network. whereas the PNDA open supply utility is tremendous for knowing what's presently occurring, by using itself it doesn't deliver prescriptive actions to take - which is important when you are attempting to ensure that the community would not get "clogged up" and decelerate for conclusion-person valued clientele. With this perception and working alongside their client, Cisco built rules around what to do with PNDA's reports to prevent network outages and preserve issues working smoothly, before complications take place. The approach helped Cisco find a market want while concurrently validating the price of extra investments into its PNDA "implementation" and "building" services systems.

combine platforms to Innovate

individual know-how platforms are the springboard for innovating new products and services. it really is how 3M used adhesives to make Command strips.

New market alternatives frequently come from combining systems. 3M's periodical table of know-how systems allows for its engineers to mix and match applied sciences to with ease explore new probabilities and quickly create new products. 3M's high efficiency Window films, as an example, are a mixture of 4 systems: Adhesives, films, Nano-expertise, and light administration. with the aid of combining these applied sciences, 3M has tapped into a lot of new markets like window tinting for vehicles, power management for business constructions through tinted glass, and security glass for home windows to avoid shattering from spoil-ins and earthquakes.

Cisco carried out an identical synergies when it utilized its "building" and "implementation" structures in its work on PNDA. via combining these two systems right into a single high cost answer for telecommunication service providers, Cisco now has an providing for other purchasers that will also be scaled across the market. 

retain It simple

while the word "platform" is as buzzwordy as "disruption" these days, any business can faucet into the vigor of technology platform innovation via retaining issues essential. define what makes your offerings in fact wonderful, classify these capabilities in anything way makes probably the most experience, after which flip people loose to explore, combine, and create solutions with purchasers that resolve actual complications.

that's how to create a way of life of innovation. and that's the way to develop into a protracted-time period innovator.

published on: Jun 19, 2018


Cisco releases new developer functionalities throughout intent-primarily based networking platform | killexams.com Real Questions and Pass4sure dumps

Cisco is releasing new developer equipment across its intent-based mostly networking platform and open APIs into Cisco DNA core, the command and control centre for campus, branch and area intent-primarily based networks. DNA middle turns the community from a mixture of hardware contraptions right into a single gadget. With the supply of network-broad APIs, Cisco said it now enables builders to without problems programme this gadget, tapping into all the analytics and perception the community can give. Cisco is also asserting that its developer neighborhood, DevNet, surpassed 500,000 individuals. Cisco is also asserting three new developer initiatives to gas its innovation ecosystem, DevNet Ecosystem change, DevNet DNA Developer middle and DevNet Code trade. 

Already, 15 Cisco companions have constructed resourceful items on the DNA core platform and are demonstrating them at Cisco are living.

In building its giant and energetic DevNet community, Cisco mentioned it launched a brand new source of innovation as the network turns into increasingly programmable.

The DevNet Ecosystem change developer initiative makes it handy to discover and share an software or platform developed for Cisco systems. DevNet Code alternate offers builders a place to entry and share utility to rapidly build next-technology purposes and workflow integrations. DevNet DNA Developer middle is a one-stop-store for developers to build functions and integrations on the DNA core platform. It provides finished substances, capabilities, use situations and gaining knowledge of materials for developers.

the new DNA core capabilities are scheduled to be purchasable during the summer. purchasers should buy these new functionalities from Cisco and its companions by way of existing subscription presents. DevNet's Ecosystem exchange, Code alternate, and DNA Developer middle are available now. Cisco and its companions offer a full lifecycle of features to aid customers streamline the journey to definitely intent-primarily based networks.


LaSalle solutions ‘riding Evolution’ at Cisco live 2018 | killexams.com Real Questions and Pass4sure dumps

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ROSEMONT, sick., June eleven, 2018 (GLOBE NEWSWIRE) -- LaSalle solutions, a leading provider of technology lifecycle management features, is exhibiting today in sales space 1851 at Cisco are living, Cisco’s annual IT and communications convention, taking location June 10–14 on the Orange County convention core in Orlando. LaSalle will be in the world of solutions all the way through the week to reveal the superior facets of LAMPSM, the company’s industry-leading cloud-based asset and preservation contract administration platform.

Cisco live offers a distinct combination of in-depth technical education, working towards and chopping-aspect perception from the experts and businesses which are surroundings the agenda for the future of know-how and company.

“Cisco reside is a very good possibility for us to join with the partners and shoppers we work with each day, in addition to to create new relationships,” referred to Steven Robb, president of the solutions neighborhood at LaSalle solutions. “we are eager for showing company to sales space 1851 how our group of consultants and business-leading LAMP platform are changing the style our clients control the lifecycle of their Cisco hardware and application.”

As a leading provider of expertise lifecycle solutions and considered one of an elite neighborhood of Cisco partners with both Gold and Lifecycle guide fame, LaSalle solutions gives you finished options that complement Cisco capabilities via asset discovery, administration and upkeep contract accuracy and optimization using LAMP.

LAMP demos can be given during the week within the LaSalle sales space, where guests will also have an opportunity to take a photo with the LaSalle-sponsored NASCAR race car parked in the middle of the business’s exhibition area.

LaSalle’s group of Cisco licensed Internetwork experts (CCIEs) are additionally at Cisco reside this week to host informational sessions in the Cisco Engagement center, room 21. periods take area these days, Monday, June 11, via Thursday, June 14, from 12:30 to 1:30 p.m. Session topics encompass the information superhighway of things (IoT), utility-described vast area community (SD-WAN), digital network architecture (DNA), gadget automation, and more.

“The technology business is consistently altering, and we're working challenging to no longer simplest adapt to these adjustments, but also be sure that our customers are doing the identical,” referred to Robb. “The heritage of LaSalle options is one of nonstop evolution. We hearken to our purchasers and work closely with our partners to develop with them as wants and know-how alternate. collectively, we're using evolution to reside miles forward of the curve.”

About LaSalle solutions

centered in 1980, LaSalle solutions is a number one provider of expertise lifecycle asset management capabilities. LaSalle permits its shoppers to enrich their expertise operations through more suitable processes, management and reporting for greater planning and return on funding. LaSalle solutions’ strategies, extraordinary customer service and strong, market-leading cloud-primarily based toolset, LAMP, permit purchasers to acquire improved enterprise results via transparency and professional results at their fingertips.

LaSalle options is a division of MB equipment Finance LLC, a subsidiary of MB financial financial institution, N.A., a business bank headquartered in Chicago. MB monetary Inc. is the publicly traded protecting business for MB fiscal financial institution, N.A. and is traded on the NASDAQ as “MBFI.”

For more guidance on LaSalle options, please visit www.lasallesolutions.com and www.YouTube.com/LaSalleSolutions.

LaSalle options and LAMP are registered trademarks of LaSalle options within the u.s..

a photo accompanying this announcement is obtainable at http://www.globenewswire.com/NewsRoom/AttachmentNg/1d9682bc-1fc6-4c29-bb4d-a28b826faed3

Press Contact Beth Kirshenberg LaSalle answers847.823.9600 advertising@elasalle.com

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650-575 exam Dumps Source : LCSAS Cisco Lifecycle Services Advanced Security

Test Code : 650-575
Test Name : LCSAS Cisco Lifecycle Services Advanced Security
Vendor Name : Cisco
Q&A : 178 Real Questions

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FDA recollects Axcil and Desirin | killexams.com real questions and Pass4sure dumps

The U.S. meals and Drug Administration announced the consider of two sexual enhancement items -- Axcil and Desirin -- because of undeclared, ingredients.

Axcil -- described as a "male enhancement" product -- and Desirin -- talked about to "promote feminine sexual characteristic" -- are over-the-counter medication allotted nationwide by using TWC world LLC of Mountain View Calif. The company initiated the voluntary take into account after FDA assessments found the products include sildenafil, the lively ingredient of a FDA-authorised drug to deal with erectile dysfunction, in addition to two analogs -- sulfosildenafil and sulfohomosildenafil.

The FDA mentioned the undeclared chemical compounds pose a threat to consumers as a result of they could have interaction with nitrates present in some prescription medication.

each Axcil and Desirin are sold via the cyber web in a 15-pill blister pack packaged in a box.

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Copyright 2007 by way of United Press foreign


OncoMed presents information on dissimilar Anti-cancer Stem cellphone programs at American affiliation for melanoma research Annual assembly | killexams.com real questions and Pass4sure dumps

OncoMed prescription drugs, Inc. (Nasdaq: OMED), a scientific-stage company developing novel therapeutics that target melanoma stem cells (CSCs), or tumor-initiating cells, these days introduced data from an oral presentation and eight poster shows at the American affiliation of cancer analysis (AACR) Annual meeting in San Diego, CA April 5-9, 2014. The analysis presented at AACR spotlight OncoMed's drug discovery platforms along with preclinical and biomarker discoveries on its scientific-stage product candidates and a number of rising product candidates. a brief abstract of each and every presentation is provided beneath.

"The 9 shows at this yr's AACR Annual meeting reveal the breadth and depth of OncoMed's preclinical research and discovery work. Encompassing a lot of our clinical- and preclinical- stage candidates, facts being presented this week highlight the mighty anti-cancer stem cell undertaking considered throughout our portfolio, the alternatives to mix our compounds with commonplace-of-care, and our ongoing biomarker identification efforts being applied to programs in clinical development," observed John Lewicki, PhD, executive vp, Chief Scientific Officer.

Oral Presentation

Timothy Hoey, PhD, OncoMed's Senior vp of cancer Biology, gave an oral presentation entitled "using PDX models for anticancer drug screening" as a part of a methods Workshop on functions of affected person Derived Xenograft fashions to Translational cancer analysis. Dr. Hoey discussed the principal function of OncoMed's affected person-derived tumor financial institution to consider anti-tumor and anti-cancer stem cellphone endeavor of its novel drug candidates; supply insights into skills scientific indications and dosing regimens; and generate and consider predictive biomarker hypotheses for software in medical trials. OncoMed has developed a big financial institution of affected person-derived tumors, comprising greater than 200 tumors from a variety of tumor types, including the targeted phenotypic, useful and genomic characterization of each and every tumor.

Poster shows

medical-stage classes

Belinda Cancilla, PhD, Director, introduced abstract #910, "NOTCH3 expression is predictive of efficacy in pancreas tumor models handled with OMP-59R5, a monoclonal antibody focused on the NOTCH2 and NOTCH3 receptors," within the Predictive Biomarker 1 Poster Session. Expression of NOTCH3 mRNA by using subsequent-era sequencing in pancreatic tumor fashions correlated with response to OncoMed's anti-Notch2/three antibody, OMP-59R5, the place tumor efficacy correlated with NOTCH3 biomarker levels. A analysis Use simplest (RUO) qPCR assay for quantifying NOTCH3 mRNA expression the usage of Formalin-fixed, Paraffin-Embedded (FFPE) samples and an immunohistochemistry (IHC) assay for measuring tiers of NOTCH3 protein in tumor samples have been developed. These assays could be used to correlate NOTCH3 ranges with patient response in ALPINE, a phase 1b/2 clinical trial of OMP-59R5 in first-line superior pancreatic cancer sufferers. OMP-59R5 is part of OncoMed's collaboration with GlaxoSmithKline (GSK).

Marcus Fischer, associate Scientist, offered summary #3048, "OMP-59R5 (Anti-Notch2/three) inhibits tumor boom and reduces cancer stem phone frequency in patient derived SCLC xenografts," within the cancer Stem cell Phenotype and performance 2 Poster Session. OMP-59R5 became enormously constructive in decreasing tumor boom and melanoma stem phone populations in fashions of small cellphone lung cancer (SCLC). treatment with OMP-59R5 elevated the expression of differentiation markers and decreased CSC and Notch pathway genes. OncoMed is at present evaluating OMP-59R5 within the phase 1b/2 PINNACLE trial in patients with SCLC.

Dr. Hoey also offered summary #1898, "The mixture of gemcitabine/nab-paclitaxel and anti-DLL4 (demcizumab) produces synergistic boom inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic melanoma," as part of the new Diagnostics, Therapeutic concentrated on, and Response Assessments Poster Session. Demcizumab, in mixture with nab-paclitaxel (Abraxane®) and gemcitabine produced profound anti-tumor pastime and anti-CSC activity in a collection of pancreatic tumor xenografts. The triple mixture of demcizumab, Abraxane and gemcitabine turned into greater efficacious compared with the combination of demcizumab plus gemcitabine alone and in several instances ended in shrinkage of tumors to undetectable stages. OncoMed is at present trying out the aggregate of demcizumab with Abraxane/gemcitabine in a part 1b look at of superior pancreatic cancer sufferers and plans to initiate a section 2 study during this patient inhabitants later this yr. The demcizumab program is a part of OncoMed's collaboration with Celgene.

Story Continues

Chun Zhang, Senior Scientist II, offered summary #2830, "Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) with the aid of mining gene expression information of human breast melanoma xenografts," within the Predictive Biomarkers 2 Poster Session. A novel six-gene signature changed into derived based on the responsiveness of breast cancer xenografts to vantictumab and has been used successfully to precisely predict the responsiveness of six extra xenograft models to this antibody. A scientific use look at various for this six-gene signature is under building and should be used in the analysis of sufferers from OncoMed's ongoing phase 1b study of vantictumab in breast melanoma. Vantictumab is a component of OncoMed's Wnt pathway collaboration with Bayer Pharma AG (Bayer).

Pete Yeung, associate Scientist, introduced summary #1907, "Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor increase and reduces tumor-initiating mobilephone frequency in patient-derived hepatocellular carcinoma and ovarian melanoma xenograft models," in the melanoma Stem cell Phenotype and function 1 poster session. Researchers at OncoMed evaluated OMP-54F28 in models of hepatocellular cancer (HCC) and ovarian melanoma, two of the three signs that are at the moment being pursued in part 1b studies of this therapeutic candidate. OMP-54F28 proven undertaking as a single-agent and in combination with sorafenib in 4 HCC fashions and exhibited single agent and mixture pastime with paclitaxel in two ovarian cancer xenografts. A marked reduction in CSC frequency became accompanied following remedy with OMP-54F28 by myself and in mixture with chemotherapy in both tumor varieties. OMP-54F28 additionally caused the differentiation of those tumors and blocked Wnt pathway genes. OMP-54F28 is a component of OncoMed's collaboration with Bayer.

Wan-Ching Yen, PhD, Senior Scientist II introduced summary #4547, "enhanced anti-tumor effect of WNT pathway antagonists in mixture with taxanes," within the mobile Cycle Mechanisms of Anticancer Drug motion Poster Session. The aggregate of Wnt pathway antagonists with taxanes in affected person-derived pancreatic or ovarian xenografts confirmed additivity and/or synergy that exceeded that observed when Wnt blockade is combined with DNA synthesis inhibitors gemcitabine and carboplatin. both Wnt pathway antagonists and taxanes are lively on the G2/M phase of the telephone cycle, which is notion to explain accompanied synergies. Taxanes are presently being mixed with either vantictumab or OMP-54F28 in distinct ongoing phase 1b stories.

"The presentations at AACR via OncoMed's scientists fortify the clinical data being generated across our development classes," pointed out Jakob Dupont, OncoMed's Chief scientific Officer. "These analysis outcomes give effective insights on capabilities combination regimens, where the addition of ordinary-of-care treatment plans may finest enhance the exercise of our anti-melanoma stem cell candidates and ebook our predictive biomarker programs."

rising Preclinical programs

Dr. Yen additionally introduced abstract #207, "twin focused on of DLL4 and VEGF signaling by using a novel bispecific antibody inhibits tumor growth and reduces cancer stem cellphone frequency," in the Stem cell enlargement and melanoma Stem mobilephone concentrated on Poster Session. OMP-305B83, OncoMed's novel high affinity bispecific antibody focused on DLL4 and VEGF established large in vivo anti-tumor efficacy in a number strong tumor xenografts, delayed tumor recurrence following termination of chemotherapy, and decreased the frequency of cancer stem cells. twin inhibition of these two targets seems to demonstrate additive anti-tumor undertaking at doses the place blockade of both goal on my own elicited sub-most desirable endeavor. OncoMed expects to file an Investigational New Drug (IND) utility with the us meals and Drug Administration for OMP-305B83 within the second half of 2014.

Austin Gurney, PhD, Senior vice chairman of Molecular and cellular Biology at OncoMed, presented summary #1764, "Inhibition of R-spondin (RSPO) signaling reduces the growth of distinctive human tumors," within the New goals and agents 1 Poster Session. Inhibition of RSPO-LGR signaling with novel anti-RSPO antibodies inhibited tumor increase in numerous affected person derived xenograft models, including ovarian, colon, non-small mobile lung and pancreatic cancers. The RSPO blockade turned into constructive in decreasing tumor growth in tumors overexpressing RSPO, including tumors with genetic translocations, suggesting that levels of RSPO expression can also function biomarkers in settling on patients surely to reply to RSPO blockade. OncoMed expects to file an IND for its lead anti-RSPO3 antibody in late 2014 or early 2015.

each the anti-DLL4/anti-VEGF antibodies and anti-RSPO programs are encompassed inside OncoMed's collaboration with Celgene.

"Our robust presence at this 12 months's AACR Annual assembly reflects the productivity of OncoMed's platform applied sciences and our commitment to continued discovery analysis, proprietary human tumor xenograft models, and predictive biomarkers," noted Paul J. Hastings, Chairman and Chief government Officer. "OncoMed's preclinical and translational drugs work informs and supports the efforts of our building company, which is presently conducting 15 medical trials for 5 anti cancer stem cellphone brokers, and fuels the boom of our pipeline of anti-cancer stem cell therapeutics, as exemplified via the presentations of in vivo tumor efficacy facts for our pre-IND candidates, OMP-305B83 and Anti-RSPO3."

About melanoma Stem Cells

cancer stem cells, or CSCs, are the subpopulation of cells in a tumor answerable for driving growth and metastasis of the tumor. CSCs, also known as tumor-initiating cells, display definite properties which encompass the ability to divide and give rise to new CSCs by the use of a process known as self-renewal and the ability to differentiate or change into the other cells that form the bulk of the tumor. general cancer medication target bulk tumor cells however have confined have an impact on on CSCs, thereby offering a path for recurrence of the tumor. OncoMed's product candidates target CSCs by using blocking off self-renewal and riding differentiation of CSCs towards a non-tumorigenic state, and additionally have an effect on bulk tumor cells. OncoMed believes its product candidates are distinctive from the existing generations of chemotherapies and focused treatment plans, and have the competencies to greatly influence melanoma medicine and the clinical outcomes of sufferers with cancer.

About OncoMed pharmaceuticals

OncoMed prescribed drugs is a clinical-stage company concentrated on discovering and establishing novel therapeutics targeting cancer stem cells. OncoMed has 5 anti-cancer product candidates in clinical development, including demcizumab (Anti-DLL4, OMP-21M18), OMP-59R5 (Anti-Notch2/3), OMP-52M51 (Anti-Notch1), vantictumab (Anti-Fzd7, OMP-18R5), and OMP-54F28 (Fzd8-Fc), which target key cancer stem phone signaling pathways including Notch and Wnt. OncoMed has two different antibodies in preclinical building, OMP-305B83 (Anti-DLL4/Anti-VEGF bispecific) and Anti-RSPO3, with Investigational New Drug filings deliberate for late 2014 or early 2015. OncoMed is additionally pursuing discovery of additional novel anti-CSC product candidates. OncoMed has fashioned strategic alliances with Celgene company, Bayer Pharma AG and GlaxoSmithKline (GSK). additional information will also be discovered on the company's site: www.oncomed.com.

ahead-looking Statements

To the extent that statements contained in this press release are not descriptions of historical information involving OncoMed prescribed drugs, they're forward-looking statements reflecting the existing beliefs and expectations of management made pursuant to the secure harbor provisions of the deepest Securities Litigation Reform Act of 1995, including OncoMed's expectations concerning the capacity of OncoMed to strengthen its research and building pipeline, including its discovery and preclinical pipeline and its anti-CSC therapeutics in clinical trials; OncoMed's potential to find and increase novel anti-CSC therapeutics; the tolerability of OncoMed's product candidates at efficacious doses; the skills of OncoMed's product candidates to greatly affect cancer medication and the medical result of sufferers with melanoma; the capabilities for a hit construction of predictive biomarkers for OncoMed's product candidates; the timing of scientific trials for OncoMed's product candidates; and the timing of Investigational New Drug filings for OncoMed's product candidates, together with OMP-305B83 and Anti-RSPO3. Such ahead-looking statements contain vast hazards and uncertainties that may trigger OncoMed's medical building courses, future consequences, performance or achievements to vary significantly from those expressed or implied by using the forward-looking statements. Such risks and uncertainties encompass, amongst others, the uncertainties inherent within the preclinical and scientific development process; the hazards and uncertainties of the regulatory approval method; OncoMed's dependence on its collaboration companions, including Celgene, GSK and Bayer, for the funding of its partnered classes; OncoMed's ability to lift additional capital to help the development of its unpartnered programs; OncoMed's dependence on the building and advertising efforts of its partners for the business success of its partnered product candidates; OncoMed's reliance on third events to habits definite preclinical reviews and all of its scientific trials; OncoMed's reliance on single supply third-celebration contract manufacturing organizations to manufacture and provide its product candidates; OncoMed's capability to validate, develop and procure regulatory popularity of accomplice diagnostics; OncoMed's capacity to obtain market acceptance and business success of its product candidates as soon as regulatory approval is done; OncoMed's ability to find, improve and commercialize extra product candidates; the capability of rivals to find, advance or commercialize competing products greater promptly or extra effectively; OncoMed's dependence on its Chairman and Chief government Officer, its Chief Scientific Officer, its Chief clinical Officer and different key executives; chance of third birthday party claims alleging infringement of patents and proprietary rights or in search of to invalidate OncoMed's patents or proprietary rights; and the skill of OncoMed's proprietary rights to offer protection to its applied sciences and product candidates. OncoMed undertakes no obligation to update or revise any forward-looking statements. For a further description of the hazards and uncertainties that could cause specific results to differ from these expressed in these ahead-searching statements, in addition to risks concerning OncoMed's business in common, see OncoMed's Annual file on kind 10-okay for the fiscal yr ended December 31, 2013, filed with the Securities and change fee on March 18, 2014.

CONTACT: Investor Contact: OncoMed prescribed drugs Shari Annes Investor family members (650) 888-0902 shari.annes@oncomed.com

Media Inquiries: BCC partners Karen L. Bergman or Michelle Corral (650) 575-1509 or (415) 794-8662 kbergman@bccpartners.com or mcorral@bccpartners.com OncoMed pharmaceuticals, Inc. brand

supply: OncoMed pharmaceuticals, Inc.

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Farmers halt auction at Satana APMC | killexams.com real questions and Pass4sure dumps

NASHIK: Farmers on Tuesday halted public sale at the Satana Agriculture Produce Market Committee (APMC) wholesale onion market for an hour and staged a street blockade in protest in opposition t low fees to the commodity in the morning session.The auction resumed an hour after the APMC officials satisfied the agitating farmers. At different APMCs within the district, the public sale of onion persisted as average with standard wholesale expenditures being recorded in the latitude of Rs seven-hundred to Rs 1,a hundred a quintal.

Satana APMC secretary A k Bhamare mentioned, "The farmers halted onion auction for an hour from 10.30 in the morning to protest the low prices. They additionally staged a 'rasta roko' backyard the main gate of the APMC. The public sale, despite the fact, resumed at 11.30 am after we satisfied them to participate in the process. The usual wholesale onion price turned into Rs 850 a quintal, whereas the minimal and highest expenses were recorded at Rs one hundred and Rs 1,300 a quintal, respectively. respectable nice onions obtained costs in the range of Rs seven hundred to 1,300 a quintal, whereas the terrible first-class ones bought fees as much as Rs 600 a quintal."

He spoke of, "The hailstorms and unseasonal rains in February and March had hit Satana tehsil, affecting the high-quality of onions. most of the crops achieving the market are of bad exceptional. due to this fact, there's massive a difference in the wholesale onion expenses. The good fine onions are getting respectable prices, while the poor first-class plants have become reduce costs."

Shetkari Sanghatana (Nashik district) president Govind Pagar spoke of, "How will the farmers live on in the event that they cannot even get well their production prices? we are able to stage demonstrations across talukas within the district if there isn't any improvement in onion costs inside a week."

An legitimate at Lasalgaon APMC observed, "the advent of onions within the range 15,000 to 18,000 quintals a day, but the excellent of onions is not so decent as most of the crop has been broken within the contemporary hailstorms and unseasonal rains. best 40 per cent of the entire arrival is of decent great."

The common wholesale onion expense at Lasalgaon changed into recorded at Rs 950 a quintal on Tuesday. The minimum and highest fees had been recorded at Rs 300 and Rs 1,478 a quintal, respectively. around 18,000 quintals of onions have been auctioned at Lasalgaon throughout the day.

At Pimpalgaon APMC, the commonplace wholesale onion expense changed into recorded at Rs 1,100 a quintal. The minimal and optimum expenditures have been recorded at Rs 351 and Rs 1,770 a quintal, respectively. round 14,000 quintals of onions were auctioned at Pimpalgaon.

The general wholesale onion fee at the Yeola APMC become recorded at Rs 700 a quintal. The minimal and optimum fees had been recorded at Rs 200 and Rs 1,000 a quintal, respectively. around 1,500 quintals of onions have been auctioned at Yela.

At Satana APMC, the usual wholesale onion price became recorded at Rs 850 a quintal. The minimal and highest prices have been recorded at Rs a hundred and Rs 1,000 a quintal, respectively. around four,500 quintals of onions have been auctioned at Satana.

normal wholesale onion fees in Nashik APMCs

APMCs Nov 29 Dec 6 Jan 13 Feb 5 April 10 April 17 April 25 can also 6

Lasalgaon 1,700 1,750 925 740 725 1,011 975 950 Pimpalgaon 1,651 1,seven-hundred 950 675 801 921 800 1,a hundred Yeola 1,300 1,600 850 650 575 750 740 700 *observe: All figures are in rupee per quintal


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References :


Dropmark : http://killexams.dropmark.com/367904/11582475
Wordpress : http://wp.me/p7SJ6L-N7
Issu : https://issuu.com/trutrainers/docs/650-575
Dropmark-Text : http://killexams.dropmark.com/367904/12105879
Blogspot : http://killexams-braindumps.blogspot.com/2017/11/ensure-your-success-with-this-650-575.html
RSS Feed : http://feeds.feedburner.com/EnsureYourSuccessWithThis650-575QuestionBank
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Google+ : https://plus.google.com/112153555852933435691/posts/hN6iUsWtHqV?hl=en
Calameo : http://en.calameo.com/books/004923526a67266c6416d
publitas.com : https://view.publitas.com/trutrainers-inc/free-pass4sure-650-575-question-bank
Box.net : https://app.box.com/s/6132epd1k1cytlizu33s1967xyjs4i9m
zoho.com : https://docs.zoho.com/file/5psibf5139b7f72954c50b772b52541c2e91f






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